26/07/2022
Certain aren’t ate foods have traditionally started suspected from impacting the fresh new gel the crystals top, however, few study are around for help otherwise refute that it impact. Our very own purpose would be to assess the relationship between diet facts and solution uric-acid profile from inside the a nationally member try of men and women in the us.
Strategies
Using analysis off 14,809 participants (six,932 males and you will 7,877 women) many years two decades and you can more mature from the 3rd National Health and Diet Test Survey (with the decades 1988–1994), we checked out the connection between the intake off purine-steeped meals, necessary protein, and you can dairy foods and you can serum levels of uric acid. Eating plan are examined that have a supper-regularity survey. We made use of multivariate linear regression to modify having ages, gender, overall times consumption, bmi, use of diuretics Altri suggerimenti, ?-blockers, allopurinol, and you can uricosuric representatives, self-claimed blood pressure and you may gout, gel creatinine top, and you will consumption off liquor.
Efficiency
The serum uric acid level increased with increasing total meat or seafood intake and decreased with increasing dairy intake. After adjusting for age, the differences in uric acid levels between the extreme quintiles of intake were 0.48 mg/dl for total meat (95% confidence interval [95% CI] 0.34, 0.61; P < 0.001 for trend), 0.16 mg/dl for seafood (95% CI 0.06, 0.27; P = 0.005 for trend), and –0.21 mg/dl for total dairy intake (95% CI –0.37, –0.04; P = 0.02 for trend). After adjusting for other covariates, the differences between the extreme quintiles were attenuated but remained significant (P < 0.05 for all comparisons). The total protein intake was not associated with the serum uric acid level in multivariate analyses (P = 0.74 for trend). Those who consumed milk 1 or more times per day had a lower serum uric acid level than did those who did not drink milk (multivariate difference –0.25 [95% CI –0.40, –0.09]; P < 0.001 for trend). Similarly, those who consumed yogurt at least once every other day had a lower serum uric acid level than did those who did not consume yogurt (multivariate difference –0.26 [95% CI –0.41, –0.12]; P < 0.001 for trend).
Achievement
This type of findings off a nationwide representative try away from adults throughout the Us recommend that highest amounts of meats and seafood application are of large solution levels of uric acid but one total proteins intake isn’t. Whole milk practices is inversely associated with solution uric-acid top.
Hyperuricemia is regarded as the forerunner away from gout, the popular type of inflammatory joint disease into the adult males ( step 1 ). Certain commonly consumed meals have traditionally already been suspected out-of affecting brand new solution uric-acid profile, but couples data come. For example, patients which have hyperuricemia or gout are usually informed to cease habitual intake regarding purine-rich ingredients such as for example meats and you can seafood ( 2 , 3 ), but study regarding the real matchmaking anywhere between these foods and you can serum levels of uric-acid was scarce. Earlier in the day metabolic education used fake packing off filtered purine ( 4-eight ) but did not elucidate the relationship to help you actual dinners. Even though highest-proteins diets usually consist of large volumes out of purines, this new uricosuric impact of this including dieting will get, actually, also straight down gel the crystals levels ( 3 , 8 , nine ). Furthermore, limited study suggest that there is certainly an inverse relationship anywhere between dairy tool use and you will solution uric acid account ( ten , eleven ). When you look at the a recent highest possible study of incident gout certainly one of people, we discovered that large meats and fish consumption alone increased the brand new danger of event gout, whenever you are high milk products consumption try defensive up against the exposure ( several ). Then, high healthy protein intake don’t help the exposure ( several ). The relationship anywhere between this type of dietary activities plus the level of solution the crystals, yet not, was not looked at contained in this cohort.